GO:0019907 cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex
| PAG Title | GO:0019907 cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex |
| PAG ID | TAX019878 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 185 |
| Information Content | Rich |
| Other IDs | GO:0019907 |
| Base PAG ID | TAX019878 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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